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Wednesday, 19 March 2014

Brain Cancer & The Impact Of A Mechanism

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By Katie Arden


Brain cancer is one of the most serious conditions seen in the field of medicine, which probably goes without saying. There are so many details to consider and each of them will be given focus when talking about how to help the aforementioned condition. Is it possible that a certain mechanism can come into play for this purpose? After reading a recent report, it seems as though this is the case and the specifics that have been outlined were, to say the least, intriguing.

Companies along the lines of Voices against Brain Cancer know all too well just how complicated this particular condition can be. Brain cancer is complex and the various cells and substances that are seen lend credence to the idea that certain drugs can come into effect, provided they are safe. In many cases, as an article on Medical Xpress detailed, therapies primarily focus on the progression of glioma, the most malignant type of cancer. The article also detailed how an FDA-approved food additive could come into play.

Medical Xpress spoke about how this food additive was surveyed by two individuals: professor of the University of Vermont Diane M. Jaworski, Ph.D., and Patrick Long, who is a former graduate of the institution. Their attention was placed on an enzyme by the name of aspartoacylase. What this does is break down another compound called N-acetyl-L-aspartate. For those who are unaware, NAA is the primary storage form of acetate seen in the brain. In general, it is able to turn genes on as well as off. In regards to glioma, NAA levels and ASPA expression are lowered.

There was work done in order to raise ASPA expression levels early on but the resulting proliferation did not prove to be positive. However, there was still hope, as the article spoke about the food additive referred to as glyceryl triacetate, which would be used in order to assist glioma patients. GTA has been utilized in the past in order to help patients with Canavan disease, which is an inherited condition that can bring damage to the brain cells. Children who are born with Canavan disease die during infancy.

The article said that when GTA was put into effect, the results that came about later on were rather successful. GTA displayed a decreased level of growth in terms of glioma stem cells and, fortunately, the healthy cells remained intact. It's clear that based off of this alone there is a greater level of potential to consider with this particular additive. Seeing as how it doesn't have much in the way of toxicity or side-effects, the proposed level of success can become even greater in time.




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