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Wednesday, 12 March 2014

Halting PLD & How It Relates To Brain Cancer

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By Rob Sutter


There could be a number of reasons as to why brain cancer could come about. It is apparent that enzymes could play a great role on the matter but what does this entail specifically? Keep in mind the presence of glioblastoma, which is regarded as the most serious type of cancer in this regard. It's likely to assume that as long as an enzyme is stopped in its tracks, matters will be made better, so what will play into this process to make it most effective?

Futurity put forth a report that spoke about a method that could help for this purpose. The report in question referred to it as a "backdoor" approach in order to help brain cancer and one of its potential triggers. It's possible that an enzyme related to glioblastoma can be stopped, which is a great point to consider when looking at organizations like Voices against Brain Cancer. Not all of the details are clear, though, which is why a learning experience is more than helpful here.

The enzyme in particular that was looked at was given the name of phospholipase D, though it isn't relevant to brain cancer alone. In fact, it is one that has been focused on while focusing on cancers the likes of breast and gastric. It's apparent that PLD has been given a tremendous amount of focus but another point to take into account is how it was able to regulate Akt. For those who are unaware, Akt is an enzyme that also plays into the growth of cancer.

PLD was given focus in this regard and it was done during a study that involved afflicted mice. Judging by the information previously stated, one would imagine that blocking the actions of Akt would prove to be of great assistance to the issue here. However, the article said that if it is blocked, the body stands a great chance of triggering an exaggerated immune response or diabetic symptoms. Akt has to be targeted, of course, but there should still be a level of urgency taken into account.

Professor Craig Lindsley spoke about the concept of the isoform related to Akt being targeted without bringing any kind of harm to the patient. Keep in mind that if Akt is not activated, the cancerous cells in the body die out, which is especially worthy of note when considering that the patient is not harmed as a result. Safety should be top priority when talking about any field of research. The focus given on certain enzymes, in my opinion, is one that can open up greater possibilities.




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